The injury-hit San Francisco 49ers sent the reigning Super Bowl champion Philadelphia Eagles crashing out of the NFL playoffs in a stunning wild-card round upset on Sunday.

Niners running back Christian McCaffrey scored two fourth-quarter touchdowns, and San Francisco¡¯s depleted defense shut down Philadelphia¡¯s offense to complete a 23-19 road win at Lincoln Financial Field.

The 49ers ¡ª who have been decimated by a deepening injury crisis that has robbed them of key personnel for much of the season ¡ª suffered yet another cruel blow in the second quarter when tight end George Kittle hobbled off with an Achilles injury.