Christophe Weber says growth and innovation are the metrics for success in Takeda Pharmaceutical Co.¡¯s $62 billion purchase of Shire PLC. The first order of business is bringing global shareholders around to Japan¡¯s biggest-ever outbound takeover.

The Takeda CEO is facing a 21 percent drop in the stock price since the company disclosed its interest in March, while Shire is trading ?9 ($12) below the offer price of roughly ?49 a share. He¡¯s also contending with some domestic shareholders who are averse to expansion as Weber looks to create a global pharmaceutical giant.

In an interview at Takeda¡¯s new Tokyo headquarters, the French-born CEO discussed his push to sell the deal overseas ¡ª and in Japan ¡ª and plans to integrate the 237-year-old drugmaker with a London-listed company with mostly U.S.-based operations.